Vol. IV · No. 19
Thursday, May 14, 2026
Issue: Spring · 2026
Established · MMXXVI
— The evidence base for longevity medicine —
Indexed by PubMed · CTG · Cochrane
Editorial team · geroevidence.com
Subscription · app.geroevidence.com
Clinical evidence · Longevity medicine · Lead

The evidence base for longevity medicine, synthesized.

A working reference for the small number of physicians treating at the frontier of geroscience — graded, dated, and citation-ready, without the supplement-stack copy.

Geroevidence indexes every trial, registry, cohort, and meta-analysis on the longevity pharmacopeia — rapamycin, metformin, GLP-1 receptor agonists, SGLT2 inhibitors, acarbose, senolytics, NMN, and the rest — and grades each on a four-tier evidence ladder running from mechanism to hard outcomes.

Each intervention has a single, dated profile. Hazard ratios are pooled with confidence intervals. New papers enter the feed within twenty-four hours of indexing, but never the profile itself until a clinician reviews them. No claim appears without a citation; no citation appears without a grade.

The platform was built for clinicians who already read the trials — not for patients, not for content marketers, and not for the wellness market.

Start 14-day free trial See a sample profile No card required · cancel any time
Fig. 1 Watchlist. Subscriber dashboard showing three of forty-seven indexed interventions, with RCT, cohort, and meta-analytic counts. Pooled hazard ratios are weighted by trial size and updated nightly. SYNC 04:12 UTC · v 1.0.0
Rapamycin
mTOR inhibitor · RAP-001
Moderate
RCT12
Cohort34
Meta3
HR 0.83 · 95% CI 0.74–0.93▲ 4 new · 7d
Metformin
Biguanide · MTF-002
Moderate
RCT28
Cohort71
Meta9
HR 0.86 · 95% CI 0.79–0.94▲ 2 new · 7d
GLP-1 RA
Incretin mimetic · GLP-007
Strong
RCT86
Cohort52
Meta21
HR 0.78 · 95% CI 0.71–0.86▲ 11 new · 7d
Above  ·  Continued — Continued: audience, editorial, subscription — § B — § E
§ B — Audience

Built for the clinicians who already read the trials.

three readerships
A — Clinic

Longevity clinic physicians

Sourcing dosing protocols, contraindications, and durable evidence summaries for patient-facing decisions across rapalogs, metformin, and incretin therapy.

  • Patient-ready summaries
  • Off-label dosing references
  • Adverse-event tracking
B — Concierge

Concierge & preventive MDs

Defending recommendations to informed patients who arrive with podcast notes and PubMed prints in hand. Evidence weight, not enthusiasm.

  • Plain-language briefs
  • Strength-of-evidence grading
  • Citation-ready exports
C — Research

Geroscience researchers

Tracking the trial pipeline across mTOR, AMPK, senolytics, and reprogramming, with weekly diffs and structured trial metadata for downstream analysis.

  • Structured trial metadata
  • Weekly literature diffs