Vol. IV · No. 19
Tuesday, June 23, 2026
Issue: Spring · 2026
Established · MMXXVI
— The evidence base for longevity medicine —
Indexed by PubMed · CTG · Cochrane
Editorial team · geroevidence.com
Subscription · app.geroevidence.com
Clinical evidence · Longevity medicine · Lead

The evidence base for longevity medicine, synthesized.

A working reference for the small number of physicians treating at the frontier of geroscience — graded, dated, and citation-ready, without the supplement-stack copy.

Geroevidence indexes every trial, registry, cohort, and meta-analysis on the longevity pharmacopeia — rapamycin, metformin, GLP-1 receptor agonists, SGLT2 inhibitors, acarbose, senolytics, NMN, and the rest — and grades each on a four-tier evidence ladder running from mechanism to hard outcomes.

Each intervention has a single, dated profile. Hazard ratios are pooled with confidence intervals. New papers enter the feed within twenty-four hours of indexing, but never the profile itself until a clinician reviews them. No claim appears without a citation; no citation appears without a grade.

The platform was built for clinicians and researchers who want the evidence without the editorial spin.

Start 14-day free trial See a sample profile No card required · cancel any time
Fig. 1 Watchlist. Subscriber dashboard showing three of 14 indexed interventions, with RCT, cohort, and meta-analytic counts. Pooled hazard ratios are weighted by trial size and updated nightly. SYNC 06:00 UTC · v 1.0.0
Rapamycin
mTOR inhibitor · RAP-001
Moderate
RCT12
Cohort34
Meta3
HR · surrogate endpoints▲ new · 7d
Metformin
Biguanide · MTF-002
Moderate
RCT28
Cohort71
Meta9
HR 0.93 · 95% CI 0.88–0.99▲ new · 7d
GLP-1 RA
Incretin mimetic · GLP-007
Strong
RCT86
Cohort52
Meta21
HR 0.80 · 95% CI 0.72–0.90▲ new · 7d
Above  ·  Continued — Continued: audience, platform, subscription — § B — § E
§ B — Audience

Built for clinicians and researchers at the frontier of geroscience.

three readerships
A — Clinic

Longevity clinic physicians

Sourcing dosing protocols, contraindications, and durable evidence summaries for patient-facing decisions across rapalogs, metformin, and incretin therapy.

  • Patient-ready summaries
  • Evidence-graded mechanism summaries
  • Adverse-event tracking
B — Concierge

Concierge & preventive MDs

Defending recommendations to informed patients who arrive with podcast notes and PubMed prints in hand. Evidence weight, not enthusiasm.

  • Plain-language briefs
  • Strength-of-evidence grading
  • Citation-ready exports
C — Research

Geroscience researchers

Tracking the trial pipeline across mTOR, AMPK, senolytics, and reprogramming, with weekly diffs and structured trial metadata for downstream analysis.

  • Structured trial metadata
  • Weekly literature diffs
§ C — Platform

Four tools. One subscription.

what you get
01 · Evidence profiles

Intervention profiles — graded to primary sources.

Every intervention has a single, dated dossier. Hazard ratios with confidence intervals. Evidence tier from Insufficient to Strong. Active trials from ClinicalTrials.gov. New papers reviewed before they appear.

View interventions →
02 · Literature feed

Daily literature alerts — reviewed before delivery.

PubMed, bioRxiv, and medRxiv indexed daily. Every paper classified by study type and summarized in plain language. Practice-changing alerts delivered by email. Nothing auto-publishes.

Start free trial →
03 · Practice directory

Longevity clinic directory — sourced from CMS NPPES.

A searchable directory of geriatric and preventive medicine practices across all 50 states. Filtered to longevity-adjacent specialties. Updated monthly from the CMS NPPES public registry. Verify currency directly with each practice.

Access in app →
04 · Trial pipeline

Active trials — synced from ClinicalTrials.gov.

Every recruiting and active trial for tracked interventions. Phase, enrollment, primary endpoint, sponsor, and estimated completion. Updated daily. Click any trial to go directly to the ClinicalTrials.gov record.

See sample profile →