Intervention Profiles

Vitamin D and longevity: what the VITAL trial and meta-analyses actually show

Vitamin D supplementation is one of the most-studied and most-misunderstood longevity interventions. Here is what the largest RCT and pooled meta-analyses actually found on mortality and cancer outcomes.

July 26, 2026  ·  9 min read

Omega-3 fish oil and longevity: the VITAL and REDUCE-IT evidence

Omega-3 fatty acids show a consistent cardiovascular signal in some trials and none in others. Here is why formulation and dose explain more of the disagreement than most coverage acknowledges.

July 26, 2026  ·  8 min read

Creatine for healthy aging: muscle, cognition, and the human evidence

Creatine has among the strongest safety and mechanistic track records of any longevity supplement. Here is what the human trial evidence shows for muscle mass, strength, and cognitive outcomes in older adults.

July 26, 2026  ·  8 min read

Curcumin and turmeric for longevity: separating bioavailability hype from evidence

Curcumin has thousands of preclinical studies and a strong anti-inflammatory rationale, but is also one of the clearest examples of a compound whose lab promise has outpaced its human trial evidence.

July 26, 2026  ·  8 min read

Melatonin and longevity: sleep, oxidative stress, and what's actually proven

Melatonin is marketed as both a sleep aid and an anti-aging antioxidant. Its evidence base for the two claims is very different in strength — here is what separates them.

July 26, 2026  ·  7 min read

Green tea and EGCG for longevity: the epidemiological and mechanistic evidence

Green tea consumption is linked to lower mortality in large cohort studies. Concentrated EGCG supplements are a different exposure with a different, more concerning safety profile.

July 26, 2026  ·  7 min read

Klotho agonists for longevity: the earliest-stage candidate in the pipeline

Klotho agonists are the earliest-stage compound class on Geroevidence's candidate list — a strong preclinical rationale with human data limited to a Phase 1b safety trial that only recently began.

July 26, 2026  ·  7 min read

Trehalose and autophagy: an emerging longevity candidate's thin human evidence

Trehalose induces autophagy through an mTOR-independent pathway in animal models. Human longevity evidence remains almost entirely absent, making it a mechanistic candidate rather than a validated intervention.

July 26, 2026  ·  6 min read

Urolithin A and longevity: mitophagy, muscle, and the human evidence

Urolithin A activates mitophagy — the selective clearance of damaged mitochondria. Here is what the published human trial data shows, and what it does not yet show.

July 19, 2026  ·  11 min read

Alpha-ketoglutarate for longevity: the TruAge trial and what the human evidence shows

A TCA cycle intermediate that serves as a cofactor for epigenetic enzymes. The TruAge trial reported biological age reduction — here is what that claim means and how strong the evidence actually is.

July 19, 2026  ·  11 min read

GlyNAC for longevity: glycine, NAC, glutathione, and the human trial evidence

GlyNAC — glycine plus N-acetylcysteine — raises glutathione and targets multiple aging hallmarks. The human RCT evidence is small but notable.

July 19, 2026  ·  10 min read

Resveratrol for longevity: an honest assessment of the evidence in 2026

Resveratrol was the most hyped longevity compound of the 2000s. Here is what the clinical trial evidence actually shows — and why the story is more complicated than either side admits.

July 19, 2026  ·  12 min read

Pterostilbene vs. resveratrol: comparing the longevity evidence

Pterostilbene is a dimethylated resveratrol analog with significantly higher bioavailability. Here is how the two compounds compare on mechanism, pharmacokinetics, and human evidence.

July 19, 2026  ·  10 min read

Astaxanthin for longevity: what the human evidence actually shows

A marine carotenoid with antioxidant potency orders of magnitude higher than vitamin E. The human longevity evidence is preliminary — here is an honest assessment.

July 19, 2026  ·  10 min read

DHEA and aging: what the human trial evidence shows

DHEA declines dramatically with age and is one of the most prescribed hormones in longevity medicine. The evidence for hard longevity outcomes is weaker than the prescribing pattern suggests.

July 19, 2026  ·  11 min read